Article
VGLL4 Selectively Represses YAP-Dependent Gene Induction and Tumorigenic Phenotypes in Breast Cancer.
Scientific reports - 21 Jul 2017
Zhang Yinglong, Shen He, Withers Henry G, Yang Nuo, Denson Kayla E, Mussell Ashley L, Truskinovsky Alexander, Fan Qingyu, Gelman Irwin H, Frangou Costa, Zhang Jianmin
Abstract excerpt
Members of the mammalian Vestigial-like (VGLL) family of transcriptional cofactors activate genes in response to a wide variety of environmental cues. Recently, VGLL proteins have been proposed to regulate key signaling networks involved in cancer development and progression. However, the biological and clinical significance of VGLL dysregulation in human breast cancer pathogenesis remains unknown. Here, we...
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