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Article

Cas9-targeted nanopore sequencing reveals epigenetic heterogeneity after de novo assembly of native full-length hepatitis B virus genomes.

Microbial genomics - 1 May 2021

Goldsmith Chloe, Cohen Damien, Dubois Anaëlle, Martinez Maria Guadalupe, Petitjean Kilian, Corlu Anne, Testoni Barbara, Hernandez-Vargas Hector, Chemin Isabelle

Abstract excerpt

Hepatitis B virus (HBV) contains a 3.2 kb DNA genome and causes acute and chronic hepatitis. HBV infection is a global health problem, with 350 million chronically infected people at increased risk of developing liver disease and hepatocellular carcinoma (HCC). Methylation of HBV DNA in a CpG context (5mCpG) can alter the expression patterns of viral genes related to infection and cellular transformation....

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Identifiers

PMID: 34003741
DOI: 10.1099/mgen.0.000507
PMCID: PMC8209722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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