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Article

Early MinION™ nanopore single-molecule sequencing technology enables the characterization of hepatitis B virus genetic complexity in clinical samples.

PloS one - 1 Jan 2018

Sauvage Virginie, Boizeau Laure, Candotti Daniel, Vandenbogaert Mathias, Servant-Delmas Annabelle, Caro Valérie, Laperche Syria

Abstract excerpt

Until recently, the method of choice to characterize viral diversity consisted in cloning PCR amplicons of full-length viral genomes and Sanger-sequencing of multiple clones. However, this is extremely laborious, time-consuming, and low-throughput. Next generation short-read sequencing appears also limited by its inability to directly sequence full-length viral genomes. The MinION™ device recently developed by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29566006
DOI: 10.1371/journal.pone.0194366
PMCID: PMC5864009

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