Article
Treg depletion attenuates irradiation-induced pulmonary fibrosis by reducing fibrocyte accumulation, inducing Th17 response, and shifting IFN-γ, IL-12/IL-4, IL-5 balance.
Immunobiology - 1 Nov 2015
Xiong Shanshan, Guo Renfeng, Yang Zhihua, Xu Long, Du Li, Li Ruoxi, Xiao Fengjun, Wang Qianjun, Zhu Maoxiang, Pan Xiujie
Abstract excerpt
Irradiation-induced pulmonary fibrosis results from thoracic radiotherapy and severely limits radiotherapy approaches. CD4(+) CD25(+) FoxP3(+) regulatory T cells (Tregs) are involved in experimentally induced murine lung fibrosis. However, the precise contribution of Tregs to irradiation-induced pulmonary fibrosis still remains unclear. We have previously established the mouse model of irradiation-induced...
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