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Performance comparison of commercial kits for isolating and detecting circulating tumor DNA.

Scandinavian journal of clinical and laboratory investigation - 1 Jul 2021

Wang Mengyan, Huang Xia, Li Xin, Guo Qiaomei, Xu Wanxing, Zhao Mingna, Wang Xueqing, Wang Lin, Lou Jiatao

Abstract excerpt

Circulating tumor DNA (ctDNA), a fraction of cell-free DNA (cfDNA) in the circulatory system, is released from tumor cells and thus carries tumor-specific genetic signatures. Using blood-derived ctDNA to detect somatic mutations has shown great value in guiding cancer targeted therapy. Isolation and detection efficiencies are the key factors affecting the performance of ctDNA detection. To optimize and...

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PMID: 33999736
DOI: 10.1080/00365513.2020.1821394

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