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Circulating Tumor DNA Assays in Clinical Cancer Research

11 May 2018

Abstract excerpt

The importance of circulating free DNA (cfDNA) in cancer clinical research was recognized in 1994 when a mutated RAS gene fragment was detected in a patient's blood sample. Up to 1% of the total circulating DNA in patients with cancer is circulating tumor DNA (ctDNA) that originates from tumor cells. As ctDNA is rapidly cleared from the blood stream and can be obtained by minimally invasive methods, it can be...

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PMID: 29931312
DOI: 10.1093/jnci/djy105

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