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Article

Noncanonical Thyroid Hormone Receptor α Action Mediates Arterial Vasodilation.

Endocrinology - 1 Jul 2021

Geist Daniela, Hönes G Sebastian, Gassen Janina, Kerp Helena, Kleinbongard Petra, Heusch Gerd, Führer Dagmar, Moeller Lars C

Abstract excerpt

CONTEXT: Hypothyroidism impairs cardiovascular health and contributes to endothelial dysfunction with reduced vasodilation. How 3,5,3'-triiodothyronine (T3) and its receptors are involved in the regulation of vasomotion is not yet fully understood. In general, thyroid hormone receptors (TRs) either influence gene expression (canonical action) or rapidly activate intracellular signaling pathways (noncanonical...

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Identifiers

PMID: 33999131
DOI: 10.1210/endocr/bqab099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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