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Article

Vascular PPARgamma controls circadian variation in blood pressure and heart rate through Bmal1.

Cell metabolism - 1 Dec 2008

Wang Ningning, Yang Guangrui, Jia Zhanjun, Zhang Hui, Aoyagi Toshinori, Soodvilai Sunhapas, Symons J David, Schnermann Jurgen B, Gonzalez Frank J, Litwin Sheldon E, Yang Tianxin

Abstract excerpt

Thiazolidinediones (TZDs) are PPARgamma activators that exhibit vasculoprotective properties. To determine the vascular function of PPARgamma, we analyzed Tie2Cre/flox and SM22Cre/flox mice. Unexpectedly, both knockout strains exhibited a significant reduction of circadian variations in blood pressure and heart rate in parallel with diminished variations in urinary norepinephrine/epinephrine excretion and...

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Identifiers

PMID: 19041764
DOI: 10.1016/j.cmet.2008.10.009
PMCID: PMC5484540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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