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Article

The Absence of PTEN in Breast Cancer Is a Driver of MLN4924 Resistance

30 Apr 2021

Abstract excerpt

Background: Numerous studies have indicated that the neddylation pathway is closely associated with tumor development. MLN4924 (Pevonedistat), an inhibitor of the NEDD8-activating E1 enzyme, is considered a promising chemotherapeutic agent. Recently, we demonstrated that neddylation of the tumor suppressor PTEN occurs under high glucose conditions and promotes breast cancer development. It has been shown,...

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PMID: 33996822
DOI: 10.3389/fcell.2021.667435

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