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Article

Glucose deprivation elicits phenotypic plasticity via ZEB1-mediated expression of NNMT.

Oncotarget - 18 Apr 2017

Kanska Justyna, Aspuria Paul-Joseph P, Taylor-Harding Barbie, Spurka Lindsay, Funari Vincent, Orsulic Sandra, Karlan Beth Y, Wiedemeyer W Ruprecht

Abstract excerpt

Glucose is considered the primary energy source for all cells, and some cancers are addicted to glucose. Here, we investigated the functional consequences of chronic glucose deprivation in serous ovarian cancer cells. We found that cells resistant to glucose starvation (glucose-restricted cells) demonstrated increased metabolic plasticity that was dependent on NNMT (Nicotinamide N-methyltransferase) expression....

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Source

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Identifiers

PMID: 28412735
DOI: 10.18632/oncotarget.15429
PMCID: PMC5432250

Genes

NNMT
ZEB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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