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SLC25A1 regulates placental development to ensure embryonic heart morphogenesis

15 Nov 2024

Abstract excerpt

22q11.2 deletion syndrome (22q11.2DS) is the most common chromosomal microdeletion syndrome. Congenital heart defects are prevalent in 22q11.2DS but the etiology is still poorly understood. In this study, we aimed to gain mechanistic insights into the heart defects that result from 22q11.2 deletion, with a focus on Slc25a1, which is located in the deletion segment. Whereas global knockout of Slc25a1 in mice...

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PMID: 39591637
DOI: 10.1242/dev.204290

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