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Article

Genetic and environmental factors regulate the type 1 diabetes gene CTSH via differential DNA methylation

1 Jan 2021

Abstract excerpt

Cathepsin H (CTSH) is a type 1 diabetes (T1D) risk gene; large-scale genetic and epidemiological studies found that T1D genetic risk correlates with high CTSH expression, rapid decline of beta-cell function, and early onset T1D. Counterintuitively, transcriptional downregulation of CTSH by proinflammatory cytokines has been shown to promote beta-cell apoptosis. Here, we potentially explain these observed...

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PMID: 33992646
DOI: 10.1016/j.jbc.2021.100774

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