Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms in the cathepsin L2 (CTSL2) gene show association with type 1 diabetes and early-onset myasthenia gravis.

Human immunology - 1 Sept 2007

Viken Marte K, Sollid Hege Dahlen, Joner Geir, Dahl-Jørgensen Knut, Rønningen Kjersti S, Undlien Dag E, Flatø Berit, Selvaag Anne M, Førre Øystein, Kvien Tore K, Thorsby Erik, Melms Arthur, Tolosa Eva, Lie Benedicte A

Abstract excerpt

Type 1 diabetes (T1D) is an autoimmune disease characterized by loss of beta cells in the pancreas. The CTSL2 gene encodes the cysteine protease cathepsin V involved in antigen presentation in human cortical thymic epithelial cells, and involvement of the protease in autoimmunity has been suggest...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Cathepsin L

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cathepsins

Share to Cysteine Endopeptidases

Share to Diabetes Mellitus, Type 1

Share to Infant

Share to Linkage Disequilibrium

Share to Myasthenia Gravis

Source

Identifiers

PMID: 17869649
DOI: 10.1016/j.humimm.2007.05.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17869649-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in the cathepsin L2 (CTSL2) gene show association with type 1 diabetes and early-onset myasthenia gravis.PMID 17869649Read ↗

CTSG polymorphisms in Chinese children with type 1 diabetes mellitus.Semantic proximity Read ↗

CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients.Semantic proximity Read ↗

A polymorphism in PTPN2 gene is associated with an earlier onset of type 1 diabetes.Semantic proximity Read ↗

CTLA4 is differentially associated with autoimmune diseases in the Dutch population.Semantic proximity Read ↗

Lack of significant effects of the type 2 diabetes susceptibility loci JAZF1, CDC123/CAMK1D, NOTCH2, ADAMTS9, THADA, and TSPAN8/LGR5 on diabetes and quantitative metabolic traits.Semantic proximity Read ↗

Genetic and environmental factors regulate the type 1 diabetes gene CTSH via differential DNA methylationSemantic proximity Read ↗

No independent role of the -1123 G>C and+2740 A>G variants in the association of PTPN22 with type 1 diabetes and juvenile idiopathic arthritis in two Caucasian populations.Semantic proximity Read ↗

Susceptibility to type 1 diabetes conferred by the PTPN22 C1858T polymorphism in the Spanish population.Semantic proximity Read ↗

Analysis of a functional BTNL2 polymorphism in type 1 diabetes, rheumatoid arthritis, and systemic lupus erythematosus.Semantic proximity Read ↗

Association between polymorphisms in cathepsin and cystatin genes with meat production and carcass traits in Italian Duroc pigs: confirmation of the effects of a cathepsin L (CTSL) gene marker.Semantic proximity Read ↗

The PTPN22gain-of-function+1858T(+) genotypes correlate with low IL-2 expression in thymomas and predispose to myasthenia gravis.Semantic proximity Read ↗

Missense mutations in theTGM2 gene encoding transglutaminase 2 are found in patients with early-onset type 2 diabetesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.