Article
Genes and environment: novel, functional polymorphism in the human cathepsin L (CTSL1) promoter disrupts a xenobiotic response element (XRE) to alter transcription and blood pressure.
Journal of hypertension - 1 Oct 2012
Mbewe-Campbell Nzali, Wei Zhiyun, Zhang Kuixing, Friese Ryan S, Mahata Manjula, Schork Andrew J, Rao Fangwen, Chiron Stephane, Biswas Nilima, Kim Hyung-Suk, Mahata Sushil K, Waalen Jill, Nievergelt Caroline M, Hook Vivian Y, O'Connor Daniel T
Abstract excerpt
BACKGROUND: Cathepsin L (CTSL1) catalyzes the formation of peptides that influence blood pressure (BP). Naturally occurring genetic variation or targeted ablation of the Ctsl1 locus in mice yield cardiovascular pathology. Here, we searched for genetic variation across the human CTSL1 locus and probed its functional effects, especially in the proximal promoter. METHODS AND RESULTS: Systematic polymorphism...
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