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Article

Total genetic contribution assessment across the human genome.

Nature communications - 14 May 2021

Li Ting, Ning Zheng, Yang Zhijian, Zhai Ranran, Zheng Chenqing, Xu Wenzheng, Wang Yipeng, Ying Kejun, Chen Yiwen, Shen Xia

Abstract excerpt

Quantifying the overall magnitude of every single locus' genetic effect on the widely measured human phenome is of great challenge. We introduce a unified modelling technique that can consistently provide a total genetic contribution assessment (TGCA) of a gene or genetic variant without thresholding genetic association signals. Genome-wide TGCA in five UK Biobank phenotype domains highlights loci such as the HLA...

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Identifiers

PMID: 33990588
DOI: 10.1038/s41467-021-23124-w
PMCID: PMC8121943

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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