Article
Multitrait genome association analysis identifies new susceptibility genes for human anthropometric variation in the GCAT cohort.
Journal of medical genetics - 1 Nov 2018
Galván-Femenía Iván, Obón-Santacana Mireia, Piñeyro David, Guindo-Martinez Marta, Duran Xavier, Carreras Anna, Pluvinet Raquel, Velasco Juan, Ramos Laia, Aussó Susanna, Mercader J M, Puig Lluis, Perucho Manuel, Torrents David, Moreno Victor, Sumoy Lauro, de Cid Rafael
Abstract excerpt
BACKGROUND: Heritability estimates have revealed an important contribution of SNP variants for most common traits; however, SNP analysis by single-trait genome-wide association studies (GWAS) has failed to uncover their impact. In this study, we applied a multitrait GWAS approach to discover additional factor of the missing heritability of human anthropometric variation. METHODS: We analysed 205 traits, including...
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