Article
S100B gene polymorphisms are associated with the S100B level and Alzheimer's disease risk by altering the miRNA binding capacity.
Aging - 12 May 2021
Wang Jiafeng, Zhou Yulan, Yang Yixia, Gao Xiang, Liu Zhibin, Hong Guanhao, Yao Lifen, Yin Jingwen, Gu Xuefeng, Li Keshen
Abstract excerpt
To examine the role of S100B in genetic susceptibility to Alzheimer's disease (AD), we conducted a case-control study to analyze four polymorphism loci (rs2839364, rs1051169, rs2300403, and rs9722) of the S100B gene and AD risk. We found an independent increased risk of AD in ApoE ε4(-) subjects carrying the rs9722 AA-genotype (OR = 2.622, 95% CI = 1.399-4.915, P = 0.003). Further investigation revealed the serum...