Article
Risk variants in the S100B gene predict elevated S100B serum concentrations in healthy individuals.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jan 2010
Hohoff Christa, Ponath Gerald, Freitag Christine M, Kästner Florian, Krakowitzky Petra, Domschke Katharina, Koelkebeck Katja, Kipp Frank, von Eiff Christof, Deckert Jürgen, Rothermundt Matthias
Abstract excerpt
Several lines of evidence suggest an important role of the S100B protein and its coding gene in different neuropathological and psychiatric disorders like dementia, bipolar affective disorders and schizophrenia. To clarify whether a direct link exists between gene and gene product, that is, whether S100B variants directly modulate S100B serum concentration, 196 healthy individuals were assessed for S100B serum...
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