Evidence for the association of the S100beta gene with low cognitive performance and dementia in the elderly.

doi:10.1038/sj.mp.4001974

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Article

Evidence for the association of the S100beta gene with low cognitive performance and dementia in the elderly.

Molecular psychiatry - 1 Sept 2007

Lambert J-C, Ferreira S, Gussekloo J, Christiansen L, Brysbaert G, Slagboom E, Cottel D, Petit T, Hauw J-J, DeKosky S T, Richard F, Berr C, Lendon C, Kamboh M Ilyas, Mann D, Christensen K, Westendorp R, Amouyel P

Abstract excerpt

Variations in the S100beta gene may be instrumental in producing a continuum from mild cognitive decline to overt dementia. After screening 25 single nucleotide polymorphisms (SNPs) in S100beta, we observed association of the rs2300403 intron 2 SNP with poorer cognitive function in three independent populations. Moreover, we detected a significant association of this SNP with increased risk of developing dementia...

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PMID: 17579612
DOI: 10.1038/sj.mp.4001974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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