S100B polymorphisms are associated with age of onset of Parkinson's disease.

doi:10.1186/s12881-018-0547-3

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Article

S100B polymorphisms are associated with age of onset of Parkinson's disease.

BMC medical genetics - 12 Mar 2018

Fardell Camilla, Zettergren Anna, Ran Caroline, Carmine Belin Andrea, Ekman Agneta, Sydow Olof, Bäckman Lars, Holmberg Björn, Dizdar Nil, Söderkvist Peter, Nissbrandt Hans

Abstract excerpt

BACKGROUND: In this study we investigated the association between SNPs in the S100B gene and Parkinson's disease (PD) in two independent Swedish cohorts. The SNP rs9722 has previously been shown to be associated with higher S100B concentrations in serum and frontal cortex in humans. S100B is widely expressed in the central nervous system and has many functions such as regulating calcium homeostasis, inflammatory...

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PMID: 29529989
DOI: 10.1186/s12881-018-0547-3
PMCID: PMC5848451

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