Article
SNPs and haplotypes in the S100B gene reveal association with schizophrenia.
Biochemical and biophysical research communications - 4 Mar 2005
Liu Jixia, Shi Yongyong, Tang Junxia, Guo Tingwei, Li Xiuxia, Yang Yifeng, Chen Qingying, Zhao Xinzhi, He Guang, Feng Guoyin, Gu Niufan, Zhu Shaomin, Liu Huijun, He Lin
Abstract excerpt
The S100B gene locates in 21q22.3 and produces neurotrophin mainly in astrocytes of CNS which can act as an extensive marker of glial cell integrity. The synaptic destabilization hypothesis (GGF/SD) suggests that the functional deficiency of growth factors like S100B is involved in the etiology of schizophrenia and the S100B serum concentration is reported to be significantly increased in patients with acute...
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