Article
A Facile Method to Engineer Mutant Kras Alleles in an Isogenic Cell Background.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021
Budagyan Konstantin, Chernoff Jonathan
Abstract excerpt
Oncogenic KRAS mutations are common in colorectal cancer (CRC), found in ~50% of tumors, and are associated with poor prognosis and resistance to therapy. There is substantial diversity of KRAS mutations observed in CRC. Importantly, emerging clinical and experimental analysis of relatively common KRAS mutations at amino acids G12, G13, A146, and Q61 suggest that each mutation differently influences the clinical...
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