Article
Validation of Isoform- and Mutation-Specific RAS Antibodies.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021
Waters Andrew M, Der Channing J
Abstract excerpt
Validation of antibody specificity is essential for the accurate evaluation of protein expression. For antibodies that recognize the gene products of the RAS family of oncogenes (HRAS, KRAS, and NRAS), an important challenge is the determination of selectivity for the four nearly identical HRAS, KRAS4A, KRAS4B, and NRAS proteins. With increasing appreciation for the distinct roles of the different RAS proteins in...
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