Use of monoclonal antibodies to detect specific mutations in formalin-fixed, paraffin-embedded tissue sections.

Abstract excerpt

Treatment options for cancer patients have changed considerably in recent years with the introduction of variable gene mutation and targeted therapy. Although molecular testing for gene mutations remains the gold standard in assessing biopsy tissues for specific mutations and for subsequent therapy, recent developments have led to the use of highly specific monoclonal antibodies to detect mutated genes in tissue...

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