Article
Bispecific and human disease-related anti-keratin rabbit monoclonal antibodies.
Experimental cell research - 15 Feb 2006
Tao Guo-Zhong, Nakamichi Ikuo, Ku Nam-On, Wang Jing, Frolkis Maria, Gong Xiaosong, Zhu Weimin, Pytela Robert, Omary M Bishr
Abstract excerpt
Rabbit antibodies may have favorable properties compared to mouse antibodies, including high affinities and better antigen recognition. We used a biochemical and reverse immunologic approach to generate and characterize rabbit anti-phospho-keratin and anti-keratin monoclonal antibodies (MAb). Human keratins 8 and 18 (K8/K18) were used as immunogens after isolation from cells pretreated with okadaic acid or...
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