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Article

Prodromal sensory neuropathy in Pink1-/- SNCAA53T double mutant Parkinson mice.

Neuropathology and applied neurobiology - 1 Dec 2021

Valek Lucie, Tran Bao, Wilken-Schmitz Annett, Trautmann Sandra, Heidler Juliana, Schmid Tobias, Brüne Bernhard, Thomas Dominique, Deller Thomas, Geisslinger Gerd, Auburger Georg, Tegeder Irmgard

Abstract excerpt

AIMS: Parkinson's disease (PD) is frequently associated with a prodromal sensory neuropathy manifesting with sensory loss and chronic pain. We have recently shown that PD-associated sensory neuropathy in patients is associated with high levels of glucosylceramides. Here, we assessed the underlying pathology and mechanisms in Pink1-/- SNCAA53T double mutant mice. METHODS: We studied nociceptive and olfactory...

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PMID: 33974284
DOI: 10.1111/nan.12734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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