Article

Prodromal Parkinson disease signs are predicted by a whole-blood inflammatory transcriptional signature in young Pink1-/- rats

2023-08-25

Abstract excerpt

<h4>Background: </h4> Parkinson disease (PD) is the fastest growing neurodegenerative disease. The molecular pathology of PD in the prodromal phase is poorly understood; as such, there are no specific prognostic or diagnostic tests. A validated Pink1 genetic knockout rat was used to model early-onset and progressive PD. Male Pink1 -/- rats exhibit progressive declines in ultrasonic vocalizations as well as hindlim...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8338cebf-54a5-53b3-8943-6d0e1dbf547b
DOI: 10.21203/rs.3.rs-3269607/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Prodromal Parkinson disease signs are predicted by a whole-blood inflammatory transcriptional signature in young Pink1-/- ratsDOI 10.21203/rs.3.rs-3269607/v1Read

Transcriptomic profiles in Parkinson’s diseaseSemantic proximity Read

Blood transcriptomics reveals a Parkinson’s disease signature and heterogeneous prodromal molecular profiles in isolated RBDSemantic proximity Read

Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammationSemantic proximity Read

Plasma acellular transcriptome contains Parkinson’s disease signatures that can inform clinical diagnosisSemantic proximity Read

Integrated profiling of single cell epigenomic and transcriptomic landscape of Parkinson’s disease mouse brainSemantic proximity Read

Blood transcriptomics of drug-naïve sporadic Parkinson’s disease patientsSemantic proximity Read

Molecular markers of early Parkinson's disease based on gene expression in bloodSemantic proximity Read

Leveraging blood RNA expression to understand Parkinson’s disease heterogeneity and progressionSemantic proximity Read

Plasma Proteomics for Parkinson’s Disease: Diagnostic Classification, Severity Association, and Therapeutic HypothesesSemantic proximity Read

Transcriptional pathobiology and multi-omics predictors for Parkinson’s diseaseSemantic proximity Read

Thyroarytenoid Muscle Gene Expression in a Rat Model of Early‐Onset Parkinson's DiseaseSemantic proximity Read

Identification of a possible proteomic biomarker in Parkinson’s disease: discovery and replication in blood, brain and cerebrospinal fluidSemantic proximity Read