Precision mouse models of Yars/dominant intermediate Charcot-Marie-Tooth disease type C and Sptlc1/hereditary sensory and autonomic neuropathy type 1.

Abstract excerpt

Animal models of neurodegenerative diseases such as inherited peripheral neuropathies sometimes accurately recreate the pathophysiology of the human disease, and sometimes accurately recreate the genetic perturbations found in patients. Ideally, models achieve both, but this is not always possible; nonetheless, such models are informative. Here we describe two animal models of inherited peripheral neuropathy:...

Topics

• Animals
• Charcot-Marie-Tooth Disease
• Disease Models, Animal
• Hereditary Sensory and Autonomic Neuropathies
• Humans
• Ligases
• Mice
• Mutation
• Peripheral Nervous System Diseases
• RNA, Transfer