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Article

Impairment of the trans-Golgi-Lysosomal Pathway Accelerates Dopaminergic Neuronal Senescence in LRRK2R1627P Rats.

Aging and disease - 27 Oct 2024

Yang Qiumei, Pang Shimin, Zhao Chunsong, Wang Yanyan, Lu Jing, Yue Zhenyu, Chan Piu

Abstract excerpt

Leucine-rich repeat kinase 2 (LRRK2)-R1628P mutation has been shown to be one of the common risk factors for Parkinson's disease (PD) in Asian populations, but the mechanism by which R1628P mutations cause neuronal dysfunction remains unknown. We used LRRK2R1627P knock-in rats (human LRRK2-R1628P corresponds to rat LRRK2-R1627P) to investigate the R1627P mutation on function of dopaminergic neurons (DANs) and...

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Identifiers

PMID: 39500355
DOI: 10.14336/AD.2024.0883
PMCID: PMC12339174

Genes

CD4
TLR4
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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