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Article

Somatic PDGFRB activating variants promote smooth muscle cell phenotype modulation in intracranial fusiform aneurysm.

Journal of biomedical science - 13 May 2024

Hao Li, Ya Xiaolong, Wu Jiaye, Tao Chuming, Ma Ruochen, Zheng Zhiyao, Mou Siqi, Ling Yiming, Yang Yingxi, Wang Jiguang, Zhang Yan, Lin Qing, Zhao Jizong

Abstract excerpt

BACKGROUND: The fusiform aneurysm is a nonsaccular dilatation affecting the entire vessel wall over a short distance. Although PDGFRB somatic variants have been identified in fusiform intracranial aneurysms, the molecular and cellular mechanisms driving fusiform intracranial aneurysms due to PDGFRB somatic variants remain poorly understood. METHODS: In this study, single-cell sequencing and immunofluorescence...

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Identifiers

PMID: 38741091
DOI: 10.1186/s12929-024-01040-7
PMCID: PMC11092182

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