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Article

Intracranial Aneurysm-Associated COL22A1 Variants Impair Cerebrovascular Structure and Barrier Integrity in Zebrafish.

International journal of molecular sciences - 16 Jun 2026

Mardhekar Vishal Y, Florat Diandra Rufin, Kakkad Yatharth, Broderick Joseph P, Sumanas Saulius

Abstract excerpt

Intracranial aneurysms (IAs) represent a major clinical concern due to their risk of rupture and the resulting morbidity and mortality. Both environmental and genetic factors contribute to IA susceptibility, yet the genetic causes of IA remain poorly understood. We previously identified several single nucleotide variants (SNVs) in collagen XXII (COL22A1) in affected individuals with IA. However, the functional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42353150
DOI: 10.3390/ijms27125434
PMCID: PMC13300400

Genes

COL22A1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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