Article
GABAergic synapses suppress intestinal innate immunity via insulin signaling in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America - 18 May 2021
Zheng Zhongfan, Zhang Xiumei, Liu Junqiang, He Ping, Zhang Shan, Zhang Yongning, Gao Jie, Yang Shengmei, Kang Na, Afridi Muhammad Irfan, Gao Shangbang, Chen Chunhong, Tu Haijun
Abstract excerpt
GABAergic neurotransmission constitutes a major inhibitory signaling mechanism that plays crucial roles in central nervous system physiology and immune cell immunomodulation. However, its roles in innate immunity remain unclear. Here, we report that deficiency in the GABAergic neuromuscular junctions (NMJs) of Caenorhabditis elegans results in enhanced resistance to pathogens, whereas pathogen infection enhances...
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