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Article

NPR-9 regulates the innate immune response in Caenorhabditis elegans by antagonizing the activity of AIB interneurons.

Cellular & molecular immunology - 1 Jan 2018

Yu Yonglin, Zhi Lingtong, Wu Qiuli, Jing Lina, Wang Dayong

Abstract excerpt

npr-9 encodes a homologue of the gastrin-releasing peptide receptor (GRPR) and is expressed in AIB interneurons. In this study, we investigated the role of NPR-9 in the neuronal control of innate immunity using the model system Caenorhabditis elegans. After exposure to Pseudomonas aeruginosa PA14, npr-9(tm1652) mutants showed resistance to infection, decreased PA14 colonization and increased expression of...

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Identifiers

PMID: 27133473
DOI: 10.1038/cmi.2016.8
PMCID: PMC5827173

Genes

GRPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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