Article
Impaired Mitochondrial Dynamics and Mitophagy in Neuronal Models of Tuberous Sclerosis Complex.
Cell reports - 18 Oct 2016
Ebrahimi-Fakhari Darius, Saffari Afshin, Wahlster Lara, Di Nardo Alessia, Turner Daria, Lewis Tommy L, Conrad Christopher, Rothberg Jonathan M, Lipton Jonathan O, Kölker Stefan, Hoffmann Georg F, Han Min-Joon, Polleux Franck, Sahin Mustafa
Abstract excerpt
Tuberous sclerosis complex (TSC) is a neurodevelopmental disease caused by TSC1 or TSC2 mutations and subsequent activation of the mTORC1 kinase. Upon mTORC1 activation, anabolic metabolism, which requires mitochondria, is induced, yet at the same time the principal pathway for mitochondrial turnover, autophagy, is compromised. How mTORC1 activation impacts mitochondrial turnover in neurons remains unknown. Here,...
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