Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions.

Neuron - 3 May 2017

Lin Mei-Yao, Cheng Xiu-Tang, Tammineni Prasad, Xie Yuxiang, Zhou Bing, Cai Qian, Sheng Zu-Hang

Abstract excerpt

Chronic mitochondrial stress is a central problem associated with neurodegenerative diseases. Early removal of defective mitochondria from axons constitutes a critical step of mitochondrial quality control. Here we investigate axonal mitochondrial response to mild stress in wild-type neurons and chronic mitochondrial defects in Amytrophic Lateral Sclerosis (ALS)- and Alzheimer's disease (AD)-linked neurons. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axons
Share to Cerebral Cortex
Share to Endosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microscopy, Immunoelectron

Share to Mitophagy

Share to Motor Neurons

Share to Spinal Cord

Share to Vesicular Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 28472658
DOI: 10.1016/j.neuron.2017.04.004
PMCID: PMC5484086

Genes

SNPH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions.PMID 28472658Read ↗

Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases.Semantic proximity Read ↗

PINK1- and PARK2-mediated local mitophagy in distal neuronal axons.Semantic proximity Read ↗

Docking of axonal mitochondria by syntaphilin controls their mobility and affects short-term facilitation.Semantic proximity Read ↗

Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer's disease patient brains.Semantic proximity Read ↗

Syntabulin-mediated anterograde transport of mitochondria along neuronal processes.Semantic proximity Read ↗

Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons.Semantic proximity Read ↗

Defective mitochondrial-lysosomal axis promotes extracellular vesicles release of mitochondrial components in Huntington’s DiseaseSemantic proximity Read ↗

Mitochondrial hitch-hiking of Pink1 mRNA supports axonal mitophagySemantic proximity Read ↗

Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondriaSemantic proximity Read ↗

In vivo imaging reveals mitophagy independence in the maintenance of axonal mitochondria during normal agingSemantic proximity Read ↗

Mitochondrial dynamic abnormalities in amyotrophic lateral sclerosisSemantic proximity Read ↗

TSG101 negatively regulates mitochondrial biogenesis in axons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.