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Article

A Proteasome Mutation Sensitizes P. falciparum Cam3.II K13C580Y Parasites to DHA and OZ439.

ACS infectious diseases - 9 Jul 2021

Rosenthal Melissa R, Ng Caroline L

Abstract excerpt

Artemisinin-based combination therapies (ACTs), the World Health Organization-recommended first-line therapy for uncomplicated falciparum malaria, has led to significant decreases in malaria-associated morbidity and mortality in the past two decades. Decreased therapeutic efficacy of artemisinins, the cornerstone of ACTs, is threatening the gains made against this disease. As such, novel therapeutics with...

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Identifiers

PMID: 33971094
DOI: 10.1021/acsinfecdis.0c00900
PMCID: PMC8500539

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