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Article

SPARC promotes pancreatic cancer cell proliferation and migration through autocrine secretion into the extracellular milieu

21 Apr 2021

Abstract excerpt

SPARC is a secreted glycoprotein that plays a complex and multifaceted role in tumour formation and progression. However, whether SPARC is an oncogene or a tumour suppressor is still unclear. Moreover, SPARC demonstrates potential in clinical pancreatic adenocarcinoma (PAAD) treatment, although it has been identified as an oncogene in some studies and a tumor suppressor in others. In the present study, a...

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PMID: 33968201
DOI: 10.3892/ol.2021.12746

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