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Article

The pyrin inflammasome aggravates inflammatory cell migration in patients with familial Mediterranean fever.

Pediatric research - 1 May 2022

Akbaba Tayfun Hilmi, Akkaya-Ulum Yeliz Z, Demir Selcan, Ozen Seza, Balci-Peynircioglu Banu

Abstract excerpt

BACKGROUND: Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by pathogenic variants of the MEFV gene, which encodes pyrin. Leukocyte migration to serosal sites is a key event during inflammation in FMF. The pyrin inflammasome is a multiprotein complex involved in inflammation. Here, we aimed to determine the relationship between inflammatory cell migration and the pyrin inflammasome in FMF...

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PMID: 33963299
DOI: 10.1038/s41390-021-01559-7

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