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Article

NLRP13 inflammasome complex is hypermethylated in familial Mediterranean fever and global methylation correlates with the disease severity.

Annals of human genetics - 1 May 2023

Caldiran Feyzanur Yildirimtepe, Deveci Koksal, Cacan Ercan

Abstract excerpt

Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by variations in the MEFV gene, which encodes the pyrin protein, a member of the inflammasomes. Despite the complex pathogenesis of FMF, epigenetic changes also play roles in the disease progression. In our previous study, we observed a relationship between NLRP13, which is one of the members of the inflammasome complex and has a pyrin...

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PMID: 36583259
DOI: 10.1111/ahg.12493

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