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Article

Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS.

Nature immunology - 1 Aug 2016

Park Yong Hwan, Wood Geryl, Kastner Daniel L, Chae Jae Jin

Abstract excerpt

Mutations in the genes encoding pyrin and mevalonate kinase (MVK) cause distinct interleukin-1β (IL-1β)-mediated autoinflammatory diseases: familial Mediterranean fever (FMF) and hyperimmunoglobulinemia D syndrome (HIDS). Pyrin forms an inflammasome when mutant or in response to bacterial modification of the GTPase RhoA. We found that RhoA activated the serine-threonine kinases PKN1 and PKN2 that bind and...

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Source

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Identifiers

PMID: 27270401
DOI: 10.1038/ni.3457
PMCID: PMC4955684

Genes

PKN1
PKN2
MVK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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