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Article

Delineation of the functional properties exhibited by the Zinc-Activated Channel (ZAC) and its high-frequency Thr128Ala variant (rs2257020) in Xenopus oocytes.

Pharmacological research - 1 Jul 2021

Madjroh Nawid, Davies Paul A, Smalley Joshua L, Kristiansen Uffe, Söderhielm Pella C, Jensen Anders A

Abstract excerpt

The signalling characteristics of the Zinc-Activated Channel (ZAC), a member of the Cys-loop receptor (CLR) superfamily, are presently poorly elucidated. The ZACN polymorphism c.454G>A encoding for the Thr128Ala variation in ZAC is found in extremely high allele frequencies across ethnicities. In this, the first study of ZAC in Xenopus oocytes by TEVC electrophysiology, ZACThr128 and ZACAla128 exhibited largely...

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PMID: 33962015
DOI: 10.1016/j.phrs.2021.105653
PMCID: PMC8248299

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