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Article

Adaptive laboratory evolution for strain engineering.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013

Winkler James, Reyes Luis H, Kao Katy C

Abstract excerpt

Complex phenotypes, such as tolerance to growth inhibitors, are difficult to rationally engineer into industrial model organisms due our poor understanding of their underlying molecular mechanisms. Adaptive evolution circumvents this issue by exploiting the linkage between growth rate and inhibitor resistance to select for mutants with enhanced tolerance. In order to aid experimentalists in the design and...

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PMID: 23417806
DOI: 10.1007/978-1-62703-299-5_11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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