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Article

Tejaas: reverse regression increases power for detecting trans-eQTLs.

Genome biology - 6 May 2021

Banerjee Saikat, Simonetti Franco L, Detrois Kira E, Kaphle Anubhav, Mitra Raktim, Nagial Rahul, Söding Johannes

Abstract excerpt

Trans-acting expression quantitative trait loci (trans-eQTLs) account for ≥70% expression heritability and could therefore facilitate uncovering mechanisms underlying the origination of complex diseases. Identifying trans-eQTLs is challenging because of small effect sizes, tissue specificity, and a severe multiple-testing burden. Tejaas predicts trans-eQTLs by performing L2-regularized "reverse" multiple...

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Identifiers

PMID: 33957961
DOI: 10.1186/s13059-021-02361-8
PMCID: PMC8101255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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