Article
Stability of Ligand-induced Protein Conformation Influences Affinity in Maltose-binding Protein.
Journal of molecular biology - 23 Jul 2021
van den Noort Marco, de Boer Marijn, Poolman Bert
Abstract excerpt
Our understanding of what determines ligand affinity of proteins is poor, even with high-resolution structures available. Both the non-covalent ligand-protein interactions and the relative free energies of available conformations contribute to the affinity of a protein for a ligand. Distant, non-binding site residues can influence the ligand affinity by altering the free energy difference between a ligand-free...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.