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The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer

7 Feb 2020

Abstract excerpt

Abstract Enhanced prostaglandin production promotes the development and progression of cancer. Prostaglandins are generated from arachidonic acid (AA) by the action of cyclooxygenase (COX) isoenzymes. However, how cancer cells are able to maintain an elevated supply of AA for prostaglandin production remains unclear. Here, by using lung cancer cell lines and clinically relevant KrasG12D-driven mouse models, we...

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PMID: 32034305
DOI: 10.1038/s41388-020-1196-5

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