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Article

Phosphoprotein network analysis of white adipose tissues unveils deregulated pathways in response to high-fat diet.

Scientific reports - 16 May 2016

Shaik Asfa Alli, Qiu Beiying, Wee Sheena, Choi Hyungwon, Gunaratne Jayantha, Tergaonkar Vinay

Abstract excerpt

Despite efforts in the last decade, signaling aberrations associated with obesity remain poorly understood. To dissect molecular mechanisms that define this complex metabolic disorder, we carried out global phosphoproteomic analysis of white adipose tissue (WAT) from mice fed on low-fat diet (LFD) and high-fat diet (HFD). We quantified phosphorylation levels on 7696 peptides, and found significant differential...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27180971
DOI: 10.1038/srep25844
PMCID: PMC4867603

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ACSS2

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