LPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in mice

Abstract excerpt

Respiratory distress syndrome (RDS), which is the leading cause of death in premature infants, is caused by surfactant deficiency. The most critical and abundant phospholipid in pulmonary surfactant is saturated phosphatidylcholine (SatPC), which is synthesized in alveolar type II cells de novo or by the deacylation-reacylation of existing phosphatidylcholine species. We recently cloned and partially...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Neonatal Health and Biochemistry
• Share to Neonatal Respiratory Health Research
• Share to Neuroscience of respiration and sleep