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Article

Infection Temperature Affects the Phenotype and Function of Chimeric Antigen Receptor T Cells Produced via Lentiviral Technology.

Frontiers in immunology - 1 Jan 2021

Jin Xin, Lu Wenyi, Zhang Meng, Xiong Xia, Sun Rui, Wei Yunxiong, He Xiaoyuan, Zhao Mingfeng

Abstract excerpt

Chimeric antigen receptor (CAR)-T cell therapy has become an important method for the treatment of hematological tumors. Lentiviruses are commonly used gene transfer vectors for preparing CAR-T cells, and the conditions for preparing CAR-T cells vary greatly. This study reported for the first time the influence of differences in infection temperature on the phenotype and function of produced CAR-T cells. Our...

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Identifiers

PMID: 33953713
DOI: 10.3389/fimmu.2021.638907
PMCID: PMC8089475

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