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Article

Epigenetic engineering for optimal chimeric antigen receptor T cell therapy

24 Aug 2022

Abstract excerpt

Recent advancements in cancer immunotherapy, such as chimeric antigen receptor (CAR)-engineered T cell therapy and immune checkpoint therapy, have significantly improved the clinical outcomes of patients with several types of cancer. To broaden its applicability further and induce durable therapeutic efficacy, it is imperative to understand how antitumor T cells elicit cytotoxic functions, survive as memory T...

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PMID: 36000807
DOI: 10.1111/cas.15541

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