Article

Engineering of CAR-less lentiviral vectors via ER retention-mediated CAR blockade

2026-06-23

Abstract excerpt

Chimeric antigen receptor (CAR)-T cell therapies have transformed the treatment of various tumor types by redirecting and activating T cells against tumor cells. However, CAR-T cell manufacturing approaches remain challenging and limit their widespread use in clinical settings. In vivo CAR-T therapy bypasses ex vivo cell manufacturing and patient preconditioning limitations; however, it faces a significant safety...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a5406da7-73da-59a6-bd2e-b1406cc699bb
DOI: 10.64898/2026.06.21.733647

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Engineering of CAR-less lentiviral vectors via ER retention-mediated CAR blockadeDOI 10.64898/2026.06.21.733647Read

Lentiviral Vectors for CAR-T and Other Cell Therapy Products: A Microbiological and Biosafety PerspectiveSemantic proximity Read

Progress in Pseudotyping Lentiviral Vectors Towards Cell-Specific Gene Delivery In VivoSemantic proximity Read

Current Non-Viral-Based Strategies to Manufacture CAR-T CellsSemantic proximity Read

Engineering strategies to safely drive CAR T-cells into the futureSemantic proximity Read

Lentivirus for CAR-T and Other Cell Therapy Products: A Microbiological and Biosafety PerspectiveSemantic proximity Read

Production of CAR T-cells by GMP-grade lentiviral vectors: latest advances and future prospectsSemantic proximity Read

Choosing the Right Tool for Genetic Engineering: Clinical Lessons from Chimeric Antigen Receptor-T CellsSemantic proximity Read

Lentiviral vector packaging and producer cell lines yield titers equivalent to the industry-standard four-plasmid processSemantic proximity Read

Efficient in vivo generation of CAR T cells using a retargeted fourth-generation lentiviral vectorSemantic proximity Read

Targeted gene delivery systems for T-cell engineeringSemantic proximity Read

Non-viral chimeric antigen receptor (CAR) T cells going viralSemantic proximity Read

Review: Sustainable Clinical Development of CAR-T Cells – Switching From Viral Transduction Towards CRISPR-Cas Gene EditingSemantic proximity Read